Perlecan expression is strongly reduced in aging cartilage but increased by physiological loading

Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution

In preclinical and clinical studies aging has been associated with a deteriorated response to antidepressant treatment. We hypothesize that such impairment is explained by an age-related decrease in brain serotonin transporter (SERT) expression associated with low testosterone (T) levels. The objectives of this study were to establish (1) if brain SERT expression is reduced by aging and (2) if ...

the respiratory exchange ratio is higher in older subjects, but is reduced by aerobic exercise training

Intrinsic viscoelasticity increases temperature in knee cartilage under physiological loading.

Metabolism of proteoglycans and hyaluronic acid has been shown to be temperature-dependent in cartilage explants, with optimal anabolic effects between 36°C and 38°C. At rest, the temperature of human knee has a value of around 33°C. We aim to show in this study that viscoelastic properties of healthy human cartilage allow its temperature to reach those optimal temperatures during physiological...

Rat adipose-derived mesenchymal stem cells aging reduction by zinc sulfate under extremely low frequency electromagnetic field exposure is associated with increased telomerase reverse transcriptase gene expression

Zinc as an essential trace element was reported to be involved in regulation of the growth and aging of cells. In this study, rat adipose-derived mesenchymal stem cells were exposed to extremely low frequency electromagnetic field (ELF-EMF) of 50 Hz and 20 mT to evaluate whether exposure to ELF-EMF in the presence of zinc sulfate (ZnSO4) affects the telomerase reverse transcriptase (...

Satellite cell proliferation is reduced in muscles of obese Zucker rats but restored with loading.

The obese Zucker rat (OZR) is a model of metabolic syndrome, which has lower skeletal muscle size than the lean Zucker rat (LZR). Because satellite cells are essential for postnatal muscle growth, this study was designed to determine whether reduced satellite cell proliferation contributes to reduced skeletal mass in OZR vs. LZR. Satellite cell proliferation was determined by a constant-release...